Villaggio Globale

Villaggio Globale, mediante un sistema di articoli connessi fra loro e scritti da scienziati, docenti universitari o da divulgatori specializzati, affronta su argomenti monotematici i problemi che preoccupano l’attuale società e stanno mettendo in pericolo la vivibilità delle generazioni future.

Studio dell'Università del Michigan

Ci si può ammalare per eccesso... di pulizia

A rischio tutti coloro che usano prodotti detergenti contenente triclosan rischiano di indebolire i loro sistemi immunitari e di essere esposti più facilmente alle malattie. Si tratta di un composto tossico della classe dei distruttori endocrini o interferenti endocrini

I giovani che usano eccessivamente saponi antibatterici contenenti triclosan, un composto chimico clorurato della famiglia dei policlorofenoli (si tratta del bifenolo A), rischiano di indebolire i loro sistemi immunitari e di essere esposti più facilmente alle malattie. Lo afferma uno studio del Dipartimento di Epidemiologia dell'Università del Michigan pubblicato nel numero di novembre della rivista online «Environmental Health Perspectives».

Il triclosan è largamente usato, oltre che nei saponi, anche nei deodoranti, nei dentifrici, nelle creme da barba, nei colluttori e perfino nei pannolini dei bambini, nelle pellicole di protezione degli alimenti e, come disinfettante, nelle borse di pronto soccorso. Ma il triclosan è un composto tossico della classe dei distruttori endocrini o interferenti endocrini (la stessa classe dei pesticidi, del Pcb e di altri inquinanti organici pericolosi), capaci cioè di interferire o modificare i cicli ormonali umani e di provocare effetti nocivi sulla salute.

La ricerca ha analizzato, tra il 2003 ed il 2006, un campione di pazienti (bambini ed adulti) esposti ad elevati livelli di triclosan e nei quali sono stati riscontrati alti livelli di un anticorpo (citomegalovirus) che è un indicatore del malfunzionamento del sistema immunitario. Infatti, i pazienti con età maggiore di 18 anni hanno avuto frequenti problemi di allergie e di raffreddore da fieno.

L'elevata esposizione al triclosan di questi soggetti derivava dall'elevato uso di prodotti igienici ed antibatterici. Da qui la conclusione che l'eccesso di pulizia, quando i prodotti per l'igiene personale contengono triclosa, è dannosa. Ma da qui anche la conclusione che sarà necessario rivedere i limiti sanitari massimi consentiti di concentrazione nei prodotti contenenti triclosan. Ulteriori ricerche dovranno chiarire meglio questi aspetti di rischio sanitario. (V. F.)

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Study suggests that being too clean can make people sick

ANN ARBOR, Mich.---Young people who are overexposed to antibacterial soaps containing triclosan may suffer more allergies, and exposure to higher levels of Bisphenol A among adults may negatively influence the immune system, a new University of Michigan School of Public Health study suggests.

Triclosan is a chemical compound widely used in products such as antibacterial soaps, toothpaste, pens, diaper bags and medical devices. Bisphenol A (BPA) is found in many plastics and, for example, as a protective lining in food cans. Both of these chemicals are in a class of environmental toxicants called endocrine-disrupting compounds (EDCs), which are believed to negatively impact human health by mimicking or affecting hormones.

Using data from the 2003-2006 National Health and Nutrition Examination Survey, U-M researchers compared urinary BPA and triclosan with cytomegalovirus (CMV) antibody levels and diagnosis of allergies or hay fever in a sample of U.S. adults and children over age 6. Allergy and hay fever diagnosis and CMV antibodies were used as two separate markers of immune alterations.

"We found that people over age 18 with higher levels of BPA exposure had higher CMV antibody levels, which suggests their cell-mediated immune system may not be functioning properly," said Erin Rees Clayton, research investigator at the U-M School of Public Health and first author on the paper.

Researchers also found that people age 18 and under with higher levels of triclosan were more likely to report diagnosis of allergies and hay fever.

There is growing concern among the scientific community and consumer groups that these EDCs are dangerous to humans at lower levels than previously thought.

"The triclosan findings in the younger age groups may support the 'hygiene hypothesis,' which maintains living in very clean and hygienic environments may impact our exposure to micro-organisms that are beneficial for development of the immune system," said Allison Aiello, associate professor at the U-M School of Public Health and principal investigator on the study.

As an antimicrobial agent found in many household products, triclosan may play a role in changing the micro-organisms to which we are exposed in such a way that our immune system development in childhood is affected.

"It is possible that a person can be too clean for their own good," said Aiello, who is also a visiting associate professor of epidemiology at Harvard.

Previous animal studies indicate that BPA and triclosan may affect the immune system, but this is the first known study to look at exposure to BPA and triclosan as it relates to human immune function, Aiello said.

One surprise finding is that with BPA exposure, age seems to matter, said Rees Clayton. In people 18 or older, higher amounts of BPA were associated with higher CMV levels, but in people younger than 18 the reverse was true.

"This suggests the timing of the exposure to BPA and perhaps the quantity and length of time we are exposed to BPA may be affecting the immune system response," Rees Clayton said.

This is just the first step, she said, but a very important one. Going forward, researchers would like to study the long-term effects of BPA and triclosan in people to see if they can establish a causal relationship.

One limitation of the study is that it measured disease and exposure simultaneously and thus shows only part of the picture, Aiello said.

"It is possible, for example, that individuals who have an allergy are more hygienic because of their condition, and that the relationship we observed is, therefore, not causal or is an example of reverse causation," Aiello said.

Contact: Laura Bailey
baileylm@umich.edu
734-647-1848

University of Michigan

http://www.umich.edu/

See podcast explaining more about Bisphenol A and triclosan (live Nov. 29):

http://ns.umich.edu/podcast/audio.php?id=1286

Environmental Health Perspectives:

http://ehp03.niehs.nih.gov/home.action.

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